Heyrovsky Biolabs
We form a vibrant and collaborative team consisting of three principal investigators, three PhD candidates, two master students, a lab technician, and two high school students. The group brings together expertise in biology, biochemistry, and physical chemistry, all within the inspiring environment of the Biophysical Chemistry Department. This multidisciplinary foundation allows to explore complex scientific questions from multiple angles and apply diverse methodologies.
Our research focuses on the nanoscopic organization of cellular membranes, extracellular traps and other membrane-associated structures. We further investigate molecular mechanisms underlying neurodegenerative diseases. To tackle these challenges, we employ cutting-edge fluorescence techniques, including Super-resolution, correlative and FRET microscopy, using custom-built single-molecule fluorescence and confocal microscopes with fluorescence lifetime detection mode. These imaging methods are complemented with fluorescence spectroscopic techniques and computational modelling to uncover behaviour of diverse biomolecules in both model and cellular systems with exceptional spatio-temporal precision.
Main topics:
Biophysical properties of lipid droplets and their implication in neurodegeneration.
Intracellular vesicular processing in the context of a neurodegenerative environment and its impact on exosome release
Nanoscopic organisation of effector proteins in membranes and associated structures of immune cells in health and disease
Interested in joining our team? Check out for the open positions!